+988338397091
 

 Elahe Mahdavian, PhD

 

Adjunct Professor

Phone: Organizational affiliation:
  Louisiana State University Shreveport(LSUS)
E-mail: Department:
elahe.mahdavian@lsus.edu Medicinal Chemistry

 

About me

 

Dr. Mahdavian has research expertise in synthetic organic chemistry, medicinal chemistry, and lead optimization of flavanoids. Through her M.S. and Ph.D. training, She has obtained extensive experience in qualitative and quantitative analytical, bio-analytical, and cell-based techniques, such as UV-Vis, NMR, HPLC, fluorescence spectroscopy, Immunoblotting, and ELISA. Her current research interests involve drug discovery for targeted cancer therapeutics, with an emphasis on the synthesis, characterization, and QSAR analysis of small bioactive flavanoid molecules, such as fusarochromanone (a fungal metabolite) and its analogs. Her research utilizes structural-based lead optimization with the goal of improving the physiochemical properties of these natural compounds to address some of their limitations in clinical use such as bioavailability, metabolism, and interactions with biological receptors. She also has interest in computeraided drug discovery using SYBYL-Tripos for pathway & target screening of drug candidates and ADMET-Simulation Plus software for optimization of drug pharmacokinetics properties and ADMET predictions.


 

 

Certificate Paper


 

Education


Tabriz University, Tabriz, IRAN B.S. 1987 Chemistry

Sharif University of Technology, Tehran, IRAN M.S. 1991 Organic Chemistry

University of South Carolina, SC, USA Ph.D. 1998 Biochemistry

Positions


2009-present  Associate Professor of Chemistry, Louisiana State University, Shreveport, LA.

2003-2009      Assistant Professor of Chemistry, Louisiana State University, Shreveport, LA.

1999-2003     Assistant Professor of Chemistry, South Carolina State University, Orangeburg, SC.

1993-1998     Research & Teaching Assistant, University of South Carolina, Columbia, SC.

List of Publications


1. “Total Synthesis of Fusarochromanone: a Potent Anti-cancer Agent”, Adelmund, S.; Solis, F.; Nicolasvu, C.;

Sangsura, S.; Landry, G.; Railey, M.; Rachal, P.; Lutz, J.; Salvatore, B. A.; and Mahdavian, E.; Manuscript in

Progress “Tetrahedron Letters”.

2. “Use of In-silico Assays for ADMET and Target Profiling of Fusarochromanone, Wynne, M.; Williams-Hart, T.;

Salvatore, B.A.; Mahdavian, E.; Submitted to the journal of in-silico Pharmacology, http://www.in-silicopharmacology.com/imedia/7232241715840055_article.pdf.

3. “Fusarochromanone Induces G1 Cell Cycle Arrest and Apoptosis in COS7 and HEK293 Cells”, Ying, G.; Chen, X.;

Chang, C.; Singh, K.; Barzegar, M.; Mahdavian, E.; Salvatore, B. A.; Huang, S.; PLOS ONE, 10 (9): 11. PMID:

25384025, PMCID: PMC4226581, 2014.

4. “Biological Activities of Fusarochromanone: A Potent Anti-Cancer Agent”, Mahdavian, E.; Williams-Hart, T.;

Furmanski, B.; Kevil, C.; Gopi, K.; Yoon-Jee, K.; Salvatore, B. A.; Huang, S.; Clifford, J.; BMC Research Notes, 7,

601. PMID: 25187308, PMCID: PMC4168212, 2014.

5. “Caspase Dependent Signaling Underlies Glioblastoma Cell Death in Response to the Fungal Metabolite, Fusarochromanone”, Mahdavian, E.; Marshall, M.; Martin, P.; Cagle, P.; Salvatore, B. A.; Quick, Q; Int J Mol Med.

34(3): 880-5. PMID: 25016928, PMCID: PMC4121350, 2014.

6. “Mitochondrial Targeting of a-Tocopheryl Tuccinate Enhances Its Pro-apototic and Anti-cancer Efficacy” Turánek, J.; Wang, X.-F.; Knötigová1, P.; Dong, L.-F.; Koudelka, S.; Mahdavian, E.; Procházka1, L.; Sangsura, S.; Vacek,

A.; Salvatore, B. A.; Neuzil, J., Free Radic Biol Med, 50: 1546-55, PMID 21402148, 2011.

7. “Mitochondrial Targeting of Vitamin E Succinate Enhances Transmission of its Activity via Mitochondrial Complex II” Dong, L.; Adlam, V.; Tilly, D.; Prochazka L.; Mahdavian, E.; Salvatore, B.; Neuzil, J., Journal of Biological Chemistry, 286:3717, PMID 21059645, 2011.

8. “Liposomal formulation of vitamin E analogs as an efficient and selective anti-cancer treatment” Turánek, J.;

Wang, X.-F.; Knötigová1, P.; Dong, L.-F.; Koudelka, S.; Mahdavian, E.; Procházka1, L.; Sangsura, S.; Vacek, A.;

Salvatore, B. A.; Neuzil, J., Applied Toxicology and Pharmacology, 237, 2009.

9. “A Novel Synthesis of Tocopheryl Amines and Amides”, Mahdavian, E.; Sangsura, S.; Landry, G.; Eytina, J.;

Salvatore, B.A., Tetrahedron Letters, 50, 19-21, 2009.

10. “Vitamin E amides, a new class of vitamin E analogues with enhanced pro-apoptotic activity” Tomic-Vatic, A.; EyTina, J.; Chapman, J.; Mahdavian E.; Neuzil, J.; Salvatore. B.A., Int. J . Cancer, 117, 188-193, 2005.

11. “Catalytic Cysteine of Thymidylate Synthase is Activated Upon Substrate Binding “, Jason Phan, J.; Mahdavian, E.; Minor, W.; Berger, S.; Spencer, H.T.; Dunlap, R.B.; Lebioda, L.; Biochemistry, 39, 6969-6978, 2000.

12. “Kinetic Studies on Drug Resistant Variants of Escherichia coli Thymidylate Synthase: Functional Effects of Amino Acid Substitutions at Residue 4”. Mahdavian, E.; Spencer, H.T.; Dunlap, R.B; Archives of Biochemistry and Biophysics, 368: 257-264, 1999.

 

Papers Presented at Professional Meetings

1. Elahe Mahdavian, and Brian Salvatore, "Synthesis of Vitamin E Analogs as Potential Anti-Cancer Agents", Bio-Research Day sponsored by NLPI, Shreveport, LA, April 2005, Poster.

2. Elahe Mahdavian, Charles Thompson, and Brian Salvatore, "Fusarochromanone and Its New Analogs as Potential Anti-Cancer & Anti-Angiogenic Compounds", College of Sciences Annual Student Research Forum, LSUS, May 2005, Poster.

3. Brian Salvatore, Elahe Mahdavian, and Jirka Neuzil, "Synthesis and Studies of a New Class of Pro-Apoptotic Amide Analogs of Tocopheryl Esters", Society for Free Radical Research 14th Annual Meeting, Queensland, Australia, December 2005, Oral.

4. Elahe Mahdavian, and Brian Salvatore, "Fusarochromanone and its Amide Analogs as Potential Anti-Cancer and Anti-Angiogenic Agents", Annual LA-BRIN Symposium, Baton Rouge, February 2006, Poster.

5. Smink Sangsura, Elahe Mahdavian, and Brian Salvatore, "The Synthesis of New Functional Domain Analogs of a-Tocopherol Succinate" LSUS College of Sciences Undergraduate Research Forum, April 2006, Oral. Elahe Mahdavian, "Biological-Activity Assessments of Fusarochromanone and its Amide analogs", Experimental Therapeutic Group, Feist Weiller Cancer Center, Shreveport, LA, June 2006, Oral.

6. Elahe Mahdavian, John Clifford, and Brian Salvatore, "Novel Derivatives of Fusarochromanone: Potential Therapeutic Compounds", American Association of Cancer Research (AACR) Annual Meeting, Los Angeles, CA, April 2007, Poster.

7. Elahe Mahdavian, Brian Salvatore, and John Clifford, "Development of Novel Anti-Cancer Agents Based on Fusarochromanone: LSUS COS Symposium, Shreveport, LA, April 2009, Oral.

8. Elahe Mahdavian, Bonnie Buckley, Mattew Sermons, John Clifford, and Brian Salvatore, "Development of Novel Anti-Cancer Agents: Regional IDeA Meeting, Charleston, SC, October 2009, Oral.

9. Elahe Mahdavian, John Clifford, and Brian Salvatore, "Development of Novel Anti-Cancer Agents Based on Fusarochromanone: LBRN Work in Progress, Shreveport, LA, December 2009, Oral.

10. Elahe Mahdavian, Bonnie Buckley, Matthew Sermons, “Development of Novel Anti-Cancer Agents”, LBRN Annual Symposium Baton Rouge, LA, January 2010, Oral.

11. Elahe Mahdavian, “Development of Novel Anti-Cancer Agents Based on Fusarochromanone”, Bioinformatics Affinity Group (BAG) Seminar Series LSUS, Shreveport, LA, February 2010, Oral.

12. Elahe Mahdavian, Bonnie Buckley, “Biosynthesis of Fusarochromanone”, LSUS College of Science Research Forum LSUS, Shreveport, LA, April 2010, Oral.

13. Elahe Mahdavian, Bonnie Buckley, John Clifford, Brian Salvatore, "Anti-Cancer Agents Based on Fusarochromanone: AACR Annual Meeting, Washington, DC, April 2010, Poster.

14. Elahe Mahdavian, Dakota Boston, Reid Grimes, “Development of Novel anti-Cancer Agents Based on Fusarochromanone”, LBRN Work In Progress, LSU-Shreveport, Shreveport, LA, September 2010, Oral.

19. Elahe Mahdavian “Development of Novel anti-Cancer Agents Based on Fusarochromanone”, Barlow Symposium, Feist Weiller Cancer Center, Shreveport, LA, September 2010, Poster.

20. Elahe Mahdavian and Brian Salvatore. “Novel Chemical Synthesis of Natural Product, Fusarochromanone”, AACR-ACS Joint Meeting on Chemistry in Cancer Research Meeting. San Diego, CA, January 2011, Poster.

21. Elahe Mahdavian, Dakota Boston, and Reid Grimes, Tara Williams-Hart, Brian Furmanski, John Clifford, Brian Salvatore. “Development of Novel Anti-Cancer Agents based on Fusarochromanone”. AACR 102nd Annual Meeting. Orlando, FL, April 2011, Poster.

22. Elahe Mahdavian, Tara Williams-Hart, Brian Furmanski, Christopher Kevil, John Clifford, and Brian Salvatore,

“Evaluation of Fusarochromanone: A Potent Inhibitor of Angiogenesis and Tumorigenesis”, IDeA meeting, Baton Rouge, LA, September 2011, Poster.

23. Vincent Goodinich, Emily Felty, Brian Salvatore, and Elahe Mahdavian, Chemical Synthesis of Novel Structural Analogs of Fusarochromanone”, IDeA meeting, Baton Rouge, LA, September 2011, Poster.

24. Mahreen, Ahmad; Salvatore, Brian; Mahdavian, Elahe. "In-vitro Cellular Assay to Determine Anti-Cancer Activity of Synthetic Fusarochromanone (FC101) and Analogs." LSUS College of Science Student Research Symposium. Shreveport, LA, April 2012, Oral.

25. Madison Wynne, Brian Salvatore, and Elahe Mahdavian. "Use of In-Silico Molecular Modeling Techniques in the Discovery of Fusarochromanone Induced Apoptotic Pathway." LSUS College of Science Student Research Symposium. Shreveport, LA, May 2013, Poster.

26. Elahe Mahdavian, “Evaluation of Fusarochromanone: A Potent Inhibitor of Angiogenesis and Tumorigenesis”, LBRN Work in Progress, LSUS, Shreveport, LA, November 2013, Oral.

27. Steven Adelmund. "Identifying the Biological Targets of Fusarochromanone Through Photoaffinity Labeling" 2014 LBRN Annual Meetting. New Orleans, LA, February 2014, Oral.

28. Elahe Mahdavian, “Evaluation of Fusarochromanone: A Potent Inhibitor of Angiogenesis and Tumorigenesis”, 12th Annual LBRN Meeting, Baton Rouge, LA, February 2014, Oral.

Other Details


 

Honors & Awards

 

2010 – LSUS College of Sciences - Outstanding Research Scholar Award.
2011 – Chair elect, American Chemical Society, North West Louisiana Section.
2012 – Chair, American Chemical Society, North West Louisiana Section.
1999 - Hollings Cancer Center Travel Award, Eight South Carolina Research Conference (SCSRC), SC.
1999 - Science & Engineering Education Scholars Program Award, University of Wisconsin, WI.
1997 - Best Poster Presentation Award, Sixth South Carolina State Wide Research Conference (SCSRC).
 
 
Grants and Research Support:
 
1. Louisiana Biomedical Research Infrastructure Network (LBRN), “Fusarochromanone Analogs as Potential Anti-
Cancer and Anti-Angiogenic Agents”, LSUS, Shreveport, LA, June 2005, ($32,586), PI.
2. Louisiana Board of Regents Support Fund (BORSF), “Enhancement of the 300MHz NMR Instrument at LSUS”,
LSUS, Shreveport, LA, June 2005, ($76,600), co-PI.
3. Louisiana Biomedical Research Infrastructure Network (LBRN), “Synthesis and Biological Assessments of
Fusarochromanone Amide Analogs”, LSUS, Shreveport, LA, June 2006, ($25,614), PI.
4. Louisiana Board of Regents Support Fund (BORSF-RCS), “Synthesis of Novel Vitamin E Analogs with Potent Anti-
Cancer Activity”, LSUS, Shreveport, LA, June 2005-May 2008, ($66,542), PI.
5. LSUS Faculty Research Grant, “Biological-Activity Assessments of Fusarochromanone Amide-Analogs: Potential
Anti-Cancer and Anti-Angiogenic Agents”, LSUS, Shreveport, LA, September 2006, ($550), PI.
6. Louisiana Biomedical Research Infrastructure Network (LBRN), “Synthesis and Assessment of Anti-Cancer and
Anti-Angiogenic Activity of Fusarochromanone and Its Analogs”, LSUS, Shreveport, LA, June 2008, ($29,126), PI.
7. Louisiana Board of Regents Support Fund (BORSF-ENH-TR), “Enhancement of the Biochemistry Laboratory
Courses at LSUS”, LEQSF (2008-9), ($72,432), PI.
8. Louisiana Board of Regents Support Fund (BORSF-ENH-TR), “Enhancement of the Chemistry Laboratory
Courses at LSUS”, LEQSF (2008-9), ($29,634), PI.
9. Louisiana Board of Regents Support Fund (BORSF-ENH-UG), “Enhancement of the Spectrometry in Biochemistry
Laboratory Courses at LSUS”, LEQSF (2008-9), ($58,200), PI.
10. Louisiana Board of Regents Support Fund (BORSF- ENH-TR), “Bridging Molecular Modeling and Chemical
Synthesis to Enhance Inquiry- Based Learning”, LEQSF (2008-9), ($89,878), co-PI.
11. Louisiana Network of Biomedical Research Excellence (INBRE-PILOT), “Development of Novel Anti-Cancer
Agents”, LSUS, Shreveport, LA, May 2009-April 2010 ($55,000), PI.
12. Louisiana Network of Biomedical Research Excellence (INBRE), “Development of Novel Anti-Cancer Agents”,
LSUS, Shreveport, LA, May 2010-April 2015 ($700,000), PI.
13. Louisiana Network of Biomedical Research Excellence (INBRE), “Assessment of Molecular Target of
Fusarochromanone”, ($642,000), co-PI.
14. Louisiana Board of Regents Support Fund (BORSF- ENH-TR), Enhancement of the Analytical Chemistry
Laboratory Course at LSU-Shreveport, May 2011 – April 2012 ($36,000), co-PI.
15. The Community Foundation Competitive Grant, “Academic Enrichment and Tutoring Program in Allendale and
Queensborough”, August 2011 – May 2012 ($17,000), co-PI.
16. American Chemical Society- IPG Proposal--Northwest Louisiana Section (Section L401), “Fuel Cells in Action:
Racing to our Future”, August 2011 – May 2012 ($2,955), co-PI.
17. NSF-Major Research Instrumentation Program. Acquisition of TEM Instrumentation at LSUS. ($182,000). May
2013 - April 2014. Co-PI.
18. American Chemical Society -Innovative Project Grant (IPG). Lighten Up Louisiana: Lets Explore Solar Energy.
($3,000). May 2013 - April 2014. PI.
19. Natural Product Group (NPG) -LSUHSC-S. “Fusarochromanone (FC101) as a novel anticancer agent”.
($15,000). Feb 2014 - June 2014. Co-PI.
20. BORSF. Acquisition of Electrochemical Workstation for Chemistry Laboratories at LSUS. ($58,000). June
2014 - May 2015. Co-PI.
21. LBRN Summer Student Research Program. “Identification of Fusarochromanone Biological Targets
Through Photoaffinity Labeling”. ($18,500). May 2013 - August 2013. Co-PI.